Mayur Deshpande
  Personal trainer in Mumbai
Nutritional Supplements Library Glutamine(L- glutamine)

Nutritional Supplements Library

Glutamine(L- glutamine)


What is Glutamine?

Glutamine is non essential amino acid found in proteins. It is one of the 20 amino acid. Glutamine is the most abundant amino acid in the body - comprising approximately half of the free amino acids in the blood and muscle. As a non-essential amino acid, it can be produced in the body by conversion from another amino acid - glutamic acid (primarily by the skeletal muscle and liver). 19 percent of a Glutamine molecule is made up of nitrogen, making it the primary conductor of nitrogen to the muscles. It is especially found in high concentrations in the brain, muscles, gut lining, lungs, heart, kidney, and liver where it has multiple and critical functions.
Glutamine supplementation have been found to improve muscle growth, prevent muscle break down, stimulate the immune system and induce healing of gastrointestinal tract. Beans, meat, fish, poultry and dairy products are all good sources of Glutamine. From bodybuilding perpetive, glutamine is best referred to as a "conditionally essential" amino acid, since as much as 2/3 rd of free amino acid pool in the body is made up by glutamine. Under conditions of intense exercise and stressful conditions Glutamine is broken down. It is classified as a "non-essential amino acid." This label may mislead some people into believing that we don't need it. But, in essence, "non-essential" means only that the body can synthesize this amino acid. It does not mean "unimportant."


What is the effective dosage of Glutamine supplementation?

The effective dosage of glutamine supplementation is 500mg to 10 gram per day.

What are the benefits of Glutamine supplementation?

• Glutamine prevents muscle catabolism (breakdown).
• Glutamine can enter the Krebs cycle and serve as a non-carbohydrate source of energy. In fact, this is the main way it usually contributes to the production of energy.
• It aids recovery from exercise.
• It helps to recover faster from surgery.
• It is also very effective in treating gastrointestinal disorders.
• It may inhibit fatty buildings inside the liver and aid treatment of cirrhosis.
• It boosts immune system function.
• It maintains muscle mass.
• It enhances glycogen storage.


What are the side effects of Glutamine supplementation?

Glutamine is very safe and effective in short term use. It is well tolerated at levels up to at least 20 grams per day and intakes of as much as 40 grams per day should induce no significant adverse effects outside of mild gastrointestinal discomfort. But long term studies are required to verify its safety over an extended period.
Cautions-
• In diabetics (both type 1 and type 2) there is high rate of Glutamine metabolism. Higher levels of Glutamine are broken down by their liver and kidneys for the production of glucose, a process called glutamine gluconeogenesis. So people with diabetics should consult their doctor before taking it. More clinical research is required on Glutamine and its correlation and effects on diabetes. The use of high doses of antioxidants, including vitamin E and various polyphenols, should be beneficial, as well as supplementation with taurine. Taurine is the one amino acid that seems to be very helpful to diabetics.