Nutritional Supplements Library
Acetyl-L-carnitine (ALC)
 

What is ALC(Acetyl-l-carnitine)?

Acetyl-l-carnitine is formed in the mitochondria when L-carnitine joins an acetyl group from acetyl CoA. Acetyl-l-Carnitine is the acetyl ester of L-carnitine.Carnitine is an amino acid that is synthesized in the liver and kidneys from lysine and methionine. This substance is also artificially produced as a dietary supplement. Carnitine can be also found in the diet in foods such as meat and dairy products.The major function of ACL is to facilitate the transport and metabolism of long-chain fatty acids into the mitochondria for beta-oxidation and energy generation. Acetyl-L-carnitine is a delivery form for both L-carnitine and acetyl groups. Acetyl-L-carnitine levels may decrease with advancing age.

The difficulty is that carnitine can be made in two mirror-image structures: the L (left) and the R (right). Many bioactive molecules synthesize in two ways; our bodies only make and use the L form. (Cheap supplements contain both L and R to reduce manufacturing costs. The R either interferes with the body?s use of the L or has far weaker activity.) But even L-carnitine isn?t an ideal supplement because of its poor absorption. So the solution is acetyl-L-carnitine, the beneficial, and highly absorbable, L-carnitine complex.


What is the dosage of ALC supplementation?

The effective dosage is 2 to 6 grams per day in divided dosage


What are the benefits of ALC supplementation?

  • It helps to lose weight by increasing fat metabolism into the mitochondria for energy production; therefore it may also enhance stamina
  • It lowers LDL (bad) cholesterol & triglyceride levels
  • It may be effective for depression experienced by the elderly
  • It improves sperm mobility in men with poorly active sperm, a problem known as asthenozoospermia,
  • It contributes to the production of the neurotransmitter acetylcholine, which is required for mental function.
  • It improves both spatial and temporal memory, and reduces the amount of oxidative damage to RNA in the brain.
  • It is a Cardioprotective.

What are the side effects of ALC supplementation?

Side effects are very rare. Mild gastrointestinal symptoms may occur in those taking acetyl-L-carnitine supplements. These include nausea, vomiting, abdominal cramps and diarrhea. Discontinue the use and consult your physician in case of any side effects.

Cautions-For adult use only. Not for children or pregnant women or lactating women.


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