Mayur Deshpande
  Personal trainer in Mumbai
Nutritional Supplements Library Phosphatidyl Serine

Nutritional Supplements Library

Phosphatidyl Serine (P S)

What is Phosphatidylserine?

Phosphatidylserine is a natural nutrient found as part of the cell membrane of cells. It is made up of a glycerophosphate skeleton linked to two fatty acid molecules and the amino acid L-serine. It is found in fish, green leafy vegetables, soybeans and rice, and is essential for the normal functioning of neuronal cell membranes. In the past, phosphatidylserine was obtained from the brain of cows. In fact, if you read some of the research studies published with phosphatidylserine, it will identify this nutrient as BC- phosphatidylserine. The BC stands for bovine cortex, or cow brain. The phosphatidylserine currently available over the counter is derived from soy and egg yolks.

Does phosphatidylserine work?

Several studies in the past in Europe have evaluated the role of oral BC-phosphatidylserine administration in both animals and humans. In general, the results have shown positive benefits in terms of mind and memory enhancement. However, we need to keep a very important point in mind. The studies with phosphatidylserine have used bovine cortex (cow's brain) as the source. But can we assume that the results with soy-derived(supplement form) phosphatidylserine would be similar?
Phosphatidylserine consists of serine attached to fatty acids. The serine molecule in phosphatidylserine found in cow brain is attached mostly to long chain polyunsaturated fatty acids such as DHA or AA (arachidonic acid).It is equally important to know that the cow brain extract is not pure phosphatidylserine. It most likely contains other brain components such as sphingolipids, sphingomyelins, and other brain constituents, which may have led to improvements in brain function. Whereas the phosphatidylserine in soy/egg yolk is basically serine attached to saturated on monounsaturated fatty acids(oleic, linolenic, and linoleic acids), along with other fats from soy, which are chemically very different than the fats found in cow brain. Therefore it is medically and scientifically improper to use the results of studies done with phosphatidylserine from cow brain and thus claim that soy/egg yolk derived phosphatidylserine is also effective.

What is the effective dosage of Phosphatidylserine supplementation?

Safe and effective dosage used in clinical studies range from 100 to 300 mg per day. Higher dosages,upto 800 mg per day have also been used safely.

What are the benefits of Phosphatidylserine supplementation?

Manufacturer claimed- Phosphatidylserine enables your brain cells to metabolize glucose and to release and bind with neurotransmitters, all of which is important to optimum brain functioning. Phosphatidylserine also increases communication between cells in your brain by increasing the number of membrane receptor sites for receiving messages. It modulates the fluidity of cell membranes which is essential to your brain cells' ability to send and receive chemical communication. It may also restore the brain's supply and output of acetylcholine, the neurotransmitter so important to enhance memory. In short it promotes brain wellness and increase memory, concentration and learning ability.
Some studies also claimed that it can lower exercise induced stress hormone (cortisol, muscle killer) production. .

What are the side effects of Phosphatidylserine supplementation?

Its side effects are minor, Occasional gastrointestinal side effects, such as nausea and indigestion, are reported.
For adult use only: not for children or pregnant or lactating women unless under a doctor's guidance.

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